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flag The 2025 Cure Bowl features South Florida and Old Dominion, both 9-3, in their first-ever meeting and first Cure Bowl appearance.

flag The 2025 StaffDNA Cure Bowl will feature the South Florida Bulls and Old Dominion Monarchs, both 9-3 with 6-2 conference records, facing off on December 17 at Camping World Stadium in Orlando. flag It marks the first meeting between the teams and the first Cure Bowl appearance for both programs. flag South Florida, aiming for its first 10-win season since 2017 and third consecutive bowl win, enters with a strong offensive ranking and an 8-4 all-time bowl record. flag Old Dominion seeks its first bowl victory since 2016 and its first 10-win season since 2016, leading the nation in rushing offense. flag The game, broadcast on ESPN, supports cancer research through the Orlando Sports Foundation, which has raised over $6.35 million since 2015.

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