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Scientists developed a new bioreactor method to mass-produce lung organoids for personalized disease research and drug testing.
Scientists at the University of Duisburg-Essen, led by Professor Diana Klein, have created a scalable, automated method for producing lung organoids using a bioreactor, advancing personalized lung disease research.
These lab-grown tissue models, derived from stem cells, mimic human lung structure better than traditional cultures and may enable high-throughput drug testing and individualized therapy prediction.
While bioreactor-grown organoids differ slightly in cell composition—showing fewer alveolar spheres—they offer a more efficient, less labor-intensive alternative to manual methods and reduce reliance on animal testing.
The technique, published in Frontiers in Bioengineering and Biotechnology, holds promise for improving cancer treatment outcomes through personalized testing, though further optimization of bioreactor design and growth conditions is needed.
Los científicos desarrollaron un nuevo método de biorreactor para producir en masa organoides pulmonares para la investigación personalizada de enfermedades y pruebas de fármacos.