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flag Inhaled nitrous oxide at 50% may rapidly ease treatment-resistant depression, with effects in 24 hours, but benefits fade without continued use.

flag A University of Birmingham study finds inhaled nitrous oxide at 50% concentration may rapidly reduce depressive symptoms in adults with treatment-resistant major depressive disorder, with effects seen within 24 hours and longer-lasting benefits from repeated treatments. flag The gas acts on brain glutamate receptors like ketamine, offering a fast-acting alternative, though benefits typically fade after a week without ongoing therapy. flag Side effects occurred at higher concentrations, emphasizing the need for controlled use. flag Researchers are preparing the first NHS trial to evaluate its long-term potential, noting current evidence is limited by trial variability.

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