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Inhaled nitrous oxide at 50% may rapidly ease treatment-resistant depression, with effects in 24 hours, but benefits fade without continued use.
A University of Birmingham study finds inhaled nitrous oxide at 50% concentration may rapidly reduce depressive symptoms in adults with treatment-resistant major depressive disorder, with effects seen within 24 hours and longer-lasting benefits from repeated treatments.
The gas acts on brain glutamate receptors like ketamine, offering a fast-acting alternative, though benefits typically fade after a week without ongoing therapy.
Side effects occurred at higher concentrations, emphasizing the need for controlled use.
Researchers are preparing the first NHS trial to evaluate its long-term potential, noting current evidence is limited by trial variability.
El óxido nitroso inhalado a 50% puede aliviar rápidamente la depresión resistente al tratamiento, con efectos en 24 horas, pero los beneficios se desvanecen sin uso continuado.