Rookie QB Shedeur Sanders starts for the Browns vs. the 49ers, aiming to improve their 3-8 record against a struggling pass defense.

Rookie quarterback Shedeur Sanders will start for the Cleveland Browns in Week 13 against the 8-4 San Francisco 49ers, seeking to build on his debut win over the Raiders. The 49ers, despite a strong defense in recent weeks, rank 26th in pass defense, allowing 241.8 yards per game and multiple 300-yard passing games. With key defenders like Nick Bosa and Fred Warner sidelined, the Browns’ offense, led by Sanders’ dual-threat potential, could exploit San Francisco’s vulnerabilities. Sanders, who has thrown for 256 yards and one touchdown in two games, will face a critical test as the Browns aim to improve their 3-8 record.