The 49ers' defense prepares to challenge Browns rookies Sanders and Judkins, who are set to play key roles.

The 49ers' defense faces a challenge this week as they prepare to confront Cleveland Browns rookies Jeremiah Sanders and Donovan Judkins, who are expected to see significant playing time. Both players are new to the NFL and have shown promise in early training camp and preseason action. The 49ers' defensive unit, known for its aggressive style, will aim to disrupt the Browns' young backfield by forcing mistakes and limiting yardage after catch. The outcome could hinge on how well the rookies handle pressure and adapt to the speed of the professional game.