Brock Purdy and the 49ers face a major challenge against Myles Garrett and the Browns’ top-ranked pass rush.

The San Francisco 49ers, led by quarterback Brock Purdy, prepare to face Cleveland Browns' dominant pass rusher Myles Garrett, who leads the NFL in sacks this season. The matchup presents a critical test for Purdy and the 49ers' offensive line as they aim to contain Garrett’s relentless pressure in a key road game.