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Scientists created a nanowire platform that preserves astrocytes' natural shape, advancing brain disease research.
Scientists have created a nanowire platform that lets astrocytes, brain cells linked to Alzheimer’s and Parkinson’s, maintain their natural star-shaped structure in lab studies for the first time.
Unlike flat surfaces that distort their shape, the transparent nanowire mats mimic brain tissue texture, enabling natural growth and branching.
Paired with label-free 3D imaging, the system allows real-time, high-resolution observation of astrocyte dynamics.
The breakthrough, led by Johns Hopkins University and the National Research Council of Italy, could advance brain-on-a-chip models, brain organoids, and research into neurological diseases, drug development, and brain injuries.
The federally funded study was published in Advanced Science.
Los científicos crearon una plataforma de nanocables que preserva la forma natural de los astrocitos, avanzando en la investigación de enfermedades cerebrales.