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A clinical trial shows metformin reduces insulin needs in type 1 diabetes patients by 12% without worsening resistance.
A new Australian clinical trial finds metformin, traditionally used for type 2 diabetes, reduces insulin needs by about 12% in people with type 1 diabetes without worsening insulin resistance, according to research published in Nature Communications.
The study involved 40 adults with long-term type 1 diabetes who took metformin or a placebo for six months, with blood sugar control maintained.
While the drug’s exact mechanism remains unclear, researchers suggest it may involve gut microbes.
The findings, if confirmed, could improve quality of life for type 1 diabetes patients, offering a low-cost, accessible treatment option.
Meanwhile, separate research raises concerns that metformin may blunt some benefits of exercise, including vascular health and fitness gains, suggesting the need for personalized treatment approaches.
Un ensayo clínico muestra que la metformina reduce en un 12% las necesidades de insulina en pacientes con diabetes tipo 1 sin empeorar la resistencia.