Brock Purdy returns to start for the 49ers in their NFC West clash against the Cardinals on November 16, 2025.

Brock Purdy has returned to the starting lineup for the San Francisco 49ers in their NFC West matchup against the Arizona Cardinals, marking his comeback after a recent absence due to injury. The game, played on November 16, 2025, is a key contest in the division race. Purdy’s return is expected to bolster the 49ers' offense as they aim to maintain momentum in the competitive NFC West.