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Chronic stress harms brain cells in mice, reducing blood flow and raising Alzheimer’s risk, researchers say.
A Penn State study published November 11, 2025, in eLife finds that chronic stress can damage type-one nNOS neurons in mice, leading to reduced brain blood flow and weakened neural activity, especially during sleep.
These rare neurons help regulate blood vessel oscillations critical for delivering oxygen and nutrients.
Their loss, triggered by stress, disrupts brain communication and may increase the risk of neurodegenerative diseases like Alzheimer’s.
Though conducted in mice, researchers believe the findings likely apply to humans due to similar brain structures.
The study was funded by the NIH and American Heart Association, with future research planned to explore links to genetic risks for dementia.
El estrés crónico daña las células cerebrales en ratones, reduciendo el flujo sanguíneo y aumentando el riesgo de Alzheimer, dicen los investigadores.