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A polypill combining three heart failure drugs improved heart function and reduced hospitalizations in a small study.
A new study presented at the American Heart Association’s 2025 Scientific Sessions found that a once-daily polypill combining three heart failure drugs—metoprolol succinate, spironolactone, and empagliflozin—improved heart function, reduced hospitalizations, boosted medication adherence, and enhanced quality of life in adults with heart failure and reduced ejection fraction.
Among 212 participants, the polypill group saw a 3.4% increase in ejection fraction, a 60% drop in heart failure-related hospitalizations, and higher drug detection rates compared to standard care.
The findings, preliminary and not yet peer-reviewed, suggest simplified treatment may help overcome adherence challenges in this complex patient population.
En un pequeño estudio, una polipíldora que combinaba tres medicamentos para la insuficiencia cardíaca mejoró la función cardíaca y redujo las hospitalizaciones.