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flag High-dose vitamin D3, targeting levels above 40 ng/mL, cut repeat heart attack risk by 52% in heart patients, a study found.

flag A large study by Intermountain Health found that targeting vitamin D3 levels above 40 ng/mL through personalized supplementation reduced the risk of a second heart attack by 52% in patients with prior heart disease. flag The TARGET-D trial followed 630 patients from 2017 to 2025, with most starting with insufficient levels and needing high doses—often over 5,000 IU daily—to reach targets. flag Unlike past trials using fixed doses, this approach monitored levels and adjusted dosing regularly, showing no safety concerns. flag While no significant change was seen in overall major cardiac events, the reduction in repeat heart attacks was consistent and notable. flag Results were presented at the American Heart Association Scientific Sessions 2025 and await peer review.

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