The 49ers play the Rams on Sunday, November 8, 2025, at 4:25 p.m. ET on FOX.

The San Francisco 49ers face the Los Angeles Rams on Sunday, November 8, 2025, with the game airing on FOX. Fans can watch live on the FOX broadcast network or stream the game via the FOX Sports app and fuboTV, which offers a free trial. The game starts at 4:25 p.m. ET.