The 49ers, led by key players with strong past performances, face the Rams' weak pass defense in a Sunday showdown.

In Week 10 of the 2025 NFL season, the San Francisco 49ers face the Los Angeles Rams, who rank 13th in pass defense, allowing 203.1 yards per game and nine touchdown passes. Several 49ers players, including wide receiver Bennie Jennings, tight end George Kittle, quarterback Mac Jones, and running back Brian Robinson Jr., are set to face a vulnerable pass defense. Jennings has averaged 62.2 receiving yards per game against the Rams over the past three seasons, while Kittle has averaged 72.2 yards per game against them since 2021. Jones has thrown for 1,832 yards with 10 touchdowns and has exceeded his passing yardage prop in four of seven games. Robinson has averaged 21.9 rushing yards per game and has hit the rushing yard over in four of eight appearances. The game is set for Sunday, November 8, at 4:25 p.m. ET.