An 18-wheeler overturned in fog on I-49, causing a fatal multi-vehicle crash that closed northbound lanes in Louisiana.

A fatal multi-vehicle crash closed all northbound lanes of I-49 in DeSoto Parish, Louisiana, early Wednesday, November 6, 2025, near the 162-mile marker, after an 18-wheeler overturned in dense fog that reduced visibility to near zero. The accident triggered a chain reaction involving several vehicles, including a pickup truck that hit the rear of another tractor-trailer. At least one fatality was confirmed, and emergency crews shut down the lanes immediately, causing major traffic delays. The interstate reopened just before 5 p.m. after cleanup and investigation.