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flag AI-driven antibody design rapidly targets new H5N1 flu strain, speeding up antiviral development.

flag AI-powered protein language models are speeding up the creation of antiviral antibodies, according to a Vanderbilt-led study published in Cell on November 4, 2025. flag Using a model called MAGE, researchers designed human antibodies targeting viral surface proteins without relying on existing templates, successfully neutralizing a previously unseen H5N1 strain. flag This approach, which leverages AI to predict antibody-virus interactions, could drastically shorten development time for treatments against emerging threats like avian flu and RSV. flag Complementary work from the University of Washington introduced RFantibody, an open-source AI tool using diffusion models to design stable antibody binders, while MIT’s BoltzGen offers another AI-driven method for targeting previously undruggable molecules. flag These advances, supported by NIH and ARPA-H, highlight a growing trend in academic research where open-source AI tools are accelerating drug discovery and expanding potential applications in infectious diseases, cancer, and autoimmune disorders.

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