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AI-driven antibody design rapidly targets new H5N1 flu strain, speeding up antiviral development.
AI-powered protein language models are speeding up the creation of antiviral antibodies, according to a Vanderbilt-led study published in Cell on November 4, 2025.
Using a model called MAGE, researchers designed human antibodies targeting viral surface proteins without relying on existing templates, successfully neutralizing a previously unseen H5N1 strain.
This approach, which leverages AI to predict antibody-virus interactions, could drastically shorten development time for treatments against emerging threats like avian flu and RSV.
Complementary work from the University of Washington introduced RFantibody, an open-source AI tool using diffusion models to design stable antibody binders, while MIT’s BoltzGen offers another AI-driven method for targeting previously undruggable molecules.
These advances, supported by NIH and ARPA-H, highlight a growing trend in academic research where open-source AI tools are accelerating drug discovery and expanding potential applications in infectious diseases, cancer, and autoimmune disorders.
El diseño de anticuerpos impulsado por IA se dirige rápidamente a la nueva cepa de gripe H5N1, acelerando el desarrollo antiviral.