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flag Pfizer's U.S. COVID-19 vaccine sales dropped 25% in Q3 2025 after CDC narrowed booster guidance, reducing demand.

flag Pfizer's U.S. sales of its Comirnaty COVID-19 vaccine fell 25% in the third quarter of 2025 to $870 million, following a shift in federal guidance that narrowed booster recommendations. flag The CDC moved away from universal annual booster advice, leaving decisions to individuals, a change influenced by health officials expressing skepticism about vaccine necessity for healthy populations. flag This, combined with a delayed rollout of updated shots and public confusion, contributed to declining demand. flag Some pharmacies initially required prescriptions or health screenings, raising access concerns, though major insurers confirmed coverage and CVS Health removed prescription requirements. flag Despite ongoing interest among older and high-risk patients, overall uptake remains low due to mixed messaging and hesitancy. flag Pfizer also reported a 50% drop in Paxlovid sales, and analysts expect similar declines for Moderna’s Spikevax.

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