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flag No. 11 Louisville dominated South Carolina State 104-45 in season opener, their largest win since 2014.

flag No. flag 11 Louisville opened its 2025-26 season with a 104-45 blowout win over South Carolina State, the largest margin of victory since 2014. flag Khani Rooths scored a career-high 20 points, while Isaac McKneely added 17, helping the Cardinals build a 59-15 halftime lead. flag Louisville shot 53.2% from the field and made 12 three-pointers, with five players in double figures. flag South Carolina State shot just 22.8% and missed its first 12 shots, committing 25 turnovers. flag The Cardinals outrebounded the Bulldogs 47-33 and will face Jackson State on Thursday.

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