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A global study finds a universal H. influenzae vaccine may be possible despite limited genetic variation and rising antibiotic resistance in non-typeable strains.
A global study analyzing over 10,000 Haemophilus influenzae genomes reveals that despite high genetic exchange, the bacterium shows limited overall variation, suggesting a universal vaccine targeting conserved features may be feasible.
Non-typeable H. influenzae (NTHi), a major cause of childhood pneumonia and ear infections, was found in over 95% of pneumonia cases in a Thai refugee camp and exhibits widespread antibiotic resistance.
While a vaccine exists for the type b strain, it does not protect against NTHi, which lacks an effective vaccine.
The findings support urgent efforts to develop a broad-spectrum vaccine and improve global surveillance, especially in low-resource settings.
Un estudio global encuentra que puede ser posible una vacuna universal contra H. influenzae a pesar de la variación genética limitada y el aumento de la resistencia a los antibióticos en cepas no tipificables.