The 49ers host the struggling Giants in a key Week 9 NFC clash, aiming to rebound while facing a weak Giants defense.

The San Francisco 49ers, favored by 2.5 points, host the New York Giants in a Week 9 NFC matchup on Sunday, November 2, at MetLife Stadium. The 49ers, 5-3, aim to rebound from a loss to the Texans, led by Christian McCaffrey, who leads the NFL in touches and yards from scrimmage. The Giants, 2-6, are without injured rookie running back Cam Skattebo and star receiver Malik Nabers, relying on rookie quarterback Jaxson Dart, who earned Offensive Rookie of the Month. The game features a 48.5-point over/under, with both teams having cleared that mark recently. The 49ers’ elite third-down efficiency and rushing attack contrast with the Giants’ struggling defense, which ranks last in EPA against outside runs. The 49ers’ defense, while inconsistent, has limited opponents’ first-possession scoring. The game marks the 36th meeting between the franchises, with the 49ers holding a narrow 22-21 edge, including a 4-4 postseason record.