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WHO-backed review confirms GLP-1 drugs cause significant weight loss, but side effects and cost limit access.
New Cochrane reviews commissioned by the WHO confirm that GLP-1 drugs—tirzepatide, semaglutide, and liraglutide—cause significant, sustained weight loss in people with obesity, with tirzepatide showing about 16% loss over 18 months, semaglutide around 11% over two years, and liraglutide 4–5% over time.
All three reduce weight more than placebo, though gastrointestinal side effects are common and may lead to discontinuation.
Long-term safety data are limited, most studies are industry-funded, and access remains restricted due to high costs, despite upcoming patent expirations and generic availability.
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La revisión respaldada por la OMS confirma que los medicamentos GLP-1 causan una pérdida de peso significativa, pero los efectos secundarios y el costo limitan su acceso.