Mac Jones starts at QB for 49ers vs. Texans as Purdy misses game with toe injury.

The San Francisco 49ers will start Mac Jones at quarterback against the Houston Texans, as Brock Purdy remains out with a right big toe injury for the sixth game this season. Wide receiver Ricky Pearsall is also inactive due to a knee injury, marking his fourth consecutive absence. Center Jake Brendel and defensive ends Bryce Huff and Yetur Gross-Matos are ruled out, while Deommodore Lenoir, Luke Gifford, and Spencer Burford are questionable. The 49ers are 4-1 with Jones starting.