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flag Pregnant women with sickle cell disease are at higher risk for early-onset preeclampsia if placental growth factor levels are below 832 pg/mL between 20 and 24 weeks.

flag Pregnant women with sickle cell disease face a higher risk of early-onset preeclampsia, a dangerous condition linked to high blood pressure and organ damage. flag A new study finds that low levels of placental growth factor (PlGF), particularly below 832 pg/mL between 20 and 24 weeks, strongly predict early-onset preeclampsia in these patients, despite their naturally elevated baseline PlGF levels. flag The research, based on 83 women with sickle cell disease, shows low PlGF correlates with poor placental blood flow and fetal growth issues. flag While limited to one center, the findings support using PlGF testing to identify at-risk pregnancies and guide early interventions. flag An international study is underway to validate a risk calculator for improved prenatal care.

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