Memphis QB Brendon Lewis is injured, so a backup may start against top-20 South Florida, which is on a roll.

Memphis faces quarterback uncertainty ahead of its American Athletic Conference clash with No. 18 South Florida, as starting QB Brendon Lewis remains day-to-day with a lower-body injury sustained in last week’s loss to UAB. Freshman A.J. Hill or Arrington Maiden could start, with the possibility of multiple quarterbacks used. The Tigers, previously ranked No. 22 and in contention for a Group of Five College Football Playoff spot, aim to rebound after their first loss, during which they were limited to 119 rushing yards. South Florida, riding a wave of momentum after a 48-13 win over Florida Atlantic, is led by two-way quarterback Byrum Brown, who has accounted for 18 touchdowns in his last four games. The Bulls’ high-tempo offense averages just 25 minutes of possession per game. Despite a poor road record, South Florida’s coach Alex Golesh remains confident, as Memphis holds a strong historical edge, winning eight of the last 10 meetings.