Actor Eric Dane, diagnosed with ALS, stars in a Grey’s Anatomy spinoff, portraying a firefighter with the disease.

Actor Eric Dane, known for Grey’s Anatomy, will guest-star in Season 2, Episode 9 of NBC’s Brilliant Minds as Matthew, a firefighter living with ALS. The role marks his first onscreen appearance since publicly disclosing his own ALS diagnosis in April 2025, which has affected his mobility. Dane, who has become an advocate for ALS research, is partnering with I Am ALS on a $1 billion campaign. His performance is expected to reflect his real-life experience with the disease, highlighting emotional and physical challenges. The episode airs on NBC, with episodes available the next day on Peacock.