No. 14 Oklahoma hosts South Carolina in a key SEC game on October 18, 2025, with Oklahoma favored by 4.5 points and a 43.5-point over/under.

On October 18, 2025, No. 14 Oklahoma faces South Carolina in a key SEC matchup at Williams-Brice Stadium. Oklahoma, ranked second in the FBS for defense, enters with a 5-1 record and a strong defensive unit led by players like Jayden Jackson and Kendal Daniels. Quarterback John Mateer, recovering from a hand injury, aims to rebound after a three-interception performance in a loss to Texas. South Carolina, 3-3 overall and 1-3 in the SEC, struggles offensively but seeks to capitalize on Oklahoma’s ball security issues. The game, broadcast on the SEC Network and streamable via free trials of FuboTV or DirecTV, features a 4.5-point spread and a 43.5-point over/under.