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flag U.S. stocks dropped on Oct. 16, 2025, amid trade tensions, shutdown fears, and bank losses, despite gains in biotech and clean energy.

flag U.S. stocks fell on October 16, 2025, as trade tensions, a potential government shutdown, and banking sector concerns weighed on markets, with regional banks declining sharply after Zions Bancorporation reported a $50 million loan loss. flag Despite positive developments in biotech, defense, and clean energy—such as FDA Breakthrough Therapy Designation for a new depression treatment and increased investment in North American lithium production—investor sentiment remained cautious due to macroeconomic uncertainty.

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