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flag Missouri, Chicago, and the U.S. saw overdose deaths decline in 2024, but daily deaths remain high and data gaps persist.

flag Missouri saw a significant drop in drug overdose deaths to 1,450 in 2024, the lowest since 2017, following a similar decline in 2023, with experts citing possible reductions in fentanyl prevalence and wider naloxone use. flag Chicago reduced overdoses by 37% since the peak through real-time data tracking and targeted responses. flag Nationally, overdose deaths fell 27% in 2024, though 220 Americans still died daily, and seven states saw increases by mid-2025. flag Despite progress, data gaps persist, including missing racial and ethnic breakdowns, and experts caution that fewer deaths don’t confirm less drug use.

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