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CRISPR therapy cut flu virus levels by over 50% in human lung chips, showing promise for broad flu treatment.
A Harvard study shows CRISPR-based therapy reduced influenza A virus levels by over 50% in human lung chips, a lab model mimicking human lung tissue.
The treatment, delivered via lung-targeting nanoparticles, slashed viral load and inflammation while minimizing off-target effects.
By targeting a conserved viral genome region, the approach may work against multiple flu strains, offering potential for broad-spectrum antivirals.
The research, supported by NIH and DARPA, advances efforts to develop faster, more effective flu treatments that overcome limitations of animal models and annual vaccine updates.
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La terapia CRISPR redujo los niveles de virus de la gripe en más del 50% en chips pulmonares humanos, mostrando una promesa para el tratamiento general de la gripe.