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Topical steroids may treat melanoma by blocking Garp, helping the immune system fight cancer, new research shows.
Topical steroid creams may help combat melanoma by blocking the Garp protein, which helps cancer evade the immune system, according to research from the Cancer Research UK Manchester Institute.
Though steroids typically suppress immunity, the study found they can trigger an anti-cancer immune response when Garp is inhibited.
Analysis of over 2,000 patients and 40 tumor samples showed lower Garp levels linked to longer survival.
Researchers believe targeting Garp could lead to new treatments for melanoma and possibly other cancers, with drug development and clinical trials underway.
The findings, published in Cancer Discovery, challenge conventional views on steroids and immunity.
Los esteroides tópicos pueden tratar el melanoma bloqueando Garp, ayudando al sistema inmunológico a combatir el cáncer, según muestra una nueva investigación.