The 49ers lost 30-19 to the Buccaneers after key linebacker Fred Warner exited early with an ankle injury, hurting their defense.

The San Francisco 49ers lost 30-19 to the Tampa Bay Buccaneers on Sunday, with a key turning point being linebacker Fred Warner's ankle injury during the game. Warner, a vital defensive leader, left the field early and did not return, significantly impacting the 49ers' defensive performance. The Buccaneers capitalized on the disruption, controlling the game's tempo and securing the victory on the road.