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flag Colts favored by 7 points over injured Cardinals in high-scoring Week 6 matchup.

flag The Indianapolis Colts, 4-1 and leading the AFC, are favored by 7 points over the struggling Arizona Cardinals in their Week 6 matchup on October 12, 2025. flag The Colts boast the NFL’s best point differential and a high-powered offense led by Daniel Jones and Jonathan Taylor, while the Cardinals face uncertainty with Kyler Murray’s availability due to a foot injury. flag Both teams have seen their games go over the total twice this season, suggesting a potentially high-scoring game. flag The predicted final score is Colts 28, Cardinals 20, with a total of 46.5 points.

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