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Italian researchers developed a nasal spray with lithium-loaded gold nanoparticles that delivers medication to the brain, reversing memory loss in mice with fewer side effects.
A nasal spray using lithium-loaded gold nanoparticles is showing promise in treating brain disorders like Alzheimer’s and bipolar disorder by delivering medication directly to the brain, bypassing the blood-brain barrier.
Developed by Italian researchers, the non-invasive method targets the hippocampus and inhibits the GSK-3β enzyme linked to memory loss and disease progression.
In mouse studies, it reversed memory deficits with lower lithium doses and fewer side effects than oral administration.
The technology, patented internationally, is being studied further for safety and broader use, with potential for human trials in the future.
Investigadores italianos desarrollaron un spray nasal con nanopartículas de oro cargadas de litio que entregan medicamentos al cerebro, revirtiendo la pérdida de memoria en ratones con menos efectos secundarios.