The 49ers beat the Rams 23-20 in OT, improving to 4-1 despite missing key players.

The San Francisco 49ers improved to 4-1 in 2025 despite missing key players like Brock Purdy, Nick Bosa, and George Kittle, defeating the Los Angeles Rams 23-20 in overtime. With quarterback Mac Jones leading backups and kicker Eddy Pineiro making crucial field goals, including a 59-yarder and an OT winner, the 49ers overcame injuries and poor red-zone efficiency to secure a pivotal NFC West win. The team forced a fumble and stopped the Rams on fourth down in overtime, marking their fifth straight victory over Los Angeles since 2019 and solidifying their status as a resilient, deep contender despite glaring weaknesses.