The Chiefs, favored despite Mahomes' injury concerns, host the Jaguars in a high-stakes Week 5 matchup.

The Kansas City Chiefs face the Jacksonville Jaguars in Week 5 of Monday Night Football, with key player injuries and defensive matchups shaping betting trends. The Chiefs are favored despite concerns over Patrick Mahomes’ availability, while the Jaguars aim to leverage their strong run defense. Over/under lines and prop bets center on rushing production and turnover potential, with analysts highlighting value in defensive stats and game script-based wagers.