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Visceral fat's metabolic activity, not just amount, links to aggressive endometrial cancer, a study finds.
A new study presented at EANM'25 links metabolically active visceral fat—fat around internal organs—to more aggressive endometrial cancer, independent of fat volume.
Analyzing PET/CT scans of 274 women, researchers found higher glucose uptake in visceral fat correlated with advanced cancer stages and lymph node spread.
The findings suggest that the fat’s biological activity, driven by inflammation, insulin resistance, and signaling molecules, may fuel tumor growth.
While current imaging isn’t yet reliable for clinical use, future advances in quantitative imaging and AI may improve risk assessment and treatment.
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La actividad metabólica de la grasa visceral, no solo la cantidad, está vinculada al cáncer endometrial agresivo, según un estudio.