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flag AI rapidly discovered enterololin, a new antibiotic that targets Crohn’s-linked gut bacteria without harming beneficial microbes, in a study published October 3, 2025.

flag AI has accelerated the discovery of a new antibiotic, enterololin, which targets harmful gut bacteria linked to Crohn’s disease without disrupting beneficial microbes. flag Developed by researchers at MIT and McMaster University using a generative AI model called DiffDock, the compound was found to bind to a key bacterial protein complex, LolCDE, in just 100 seconds. flag Lab and mouse studies confirmed its effectiveness in reducing inflammation and harmful bacteria while preserving the microbiome, outperforming traditional antibiotics. flag The AI-driven insight cut development time and cost significantly, representing a major advance in precision antibiotic design. flag The findings were published in Nature Microbiology on October 3, 2025.

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