The winless Tennessee Titans host the 2-2 Arizona Cardinals, seeking their first win amid roster injuries and struggles.

The Tennessee Titans, winless at 0-4 and outscored by 69 points, face the 2-2 Arizona Cardinals in Glendale, Ariz., aiming for their first win. Rookie quarterback Cam Ward, the No. 1 overall pick, criticized the team’s effort after a 26-0 loss to Houston, where he posted season lows in yards (108) and completion rate (38.5%). Despite struggles, Ward said he’s had constructive locker room conversations and remains confident. Arizona, coming off two narrow losses, including a 23-20 overtime defeat to Seattle where Kyler Murray rallied the team, lost running backs Trey Benson and James Conner to season-ending injuries, leading to the signing of Michael Carter. Tennessee is also dealing with multiple injuries, including Calvin Ridley, JC Latham, Blake Hance, and Bryce Oliver. Arizona has won the past three meetings, including a 38-13 victory in 2021.