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A genetic variant linked to higher Alzheimer’s risk in ethnic Chinese, especially with APOE-ε4, accelerates brain damage and cognitive decline.
A HKUST study identifies a genetic variant, TREM2 H157Y, that greatly increases Alzheimer’s risk in ethnic Chinese, with effects similar to APOE-ε4.
Found in about 1 in 200 Chinese with AD, it accelerates cognitive decline and brain damage, especially when combined with APOE-ε4.
The research, based on the HKCeND Biobank, reveals immune, vascular, and bone-related biomarker disruptions, highlighting the need for diverse genetic studies and personalized approaches to prevention and treatment.
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Una variante genética ligada a un mayor riesgo de Alzheimer en chinos étnicos, especialmente con APOE-ε4, acelera el daño cerebral y el deterioro cognitivo.