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UK patients on sertraline warned to avoid grapefruit juice, alcohol, and certain supplements due to dangerous interactions.
People in the UK taking sertraline, a common antidepressant, have been warned by the NHS to avoid grapefruit juice, alcohol, and certain supplements due to potential dangerous interactions.
Grapefruit juice can increase sertraline levels in the blood by blocking the CYP3A4 enzyme, raising the risk of side effects.
Similar effects may occur with Seville oranges and tangelos.
Alcohol may reduce the drug’s effectiveness and worsen side effects.
Sertraline can also interact poorly with blood thinners, NSAIDs, MAOI antidepressants, St John’s wort, and other supplements.
Patients are urged to inform their doctor about all medications and supplements they are using.
Se advirtió a los pacientes del Reino Unido que toman sertralina que eviten el jugo de toronja, el alcohol y ciertos suplementos debido a interacciones peligrosas.