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Menopause alters MS onset and progression in women, affecting symptoms, comorbidities, and mortality, per a 2025 study.
A new study presented at ECTRIMS 2025 analyzing 864 MS patients found menopause significantly affects how MS begins and progresses in women.
Premenopausal women more often had optic nerve symptoms at onset and higher rates of psychiatric conditions, while postmenopausal women and men were more likely to have spinal cord onset and greater comorbidities like cardiovascular disease and metabolic disorders.
Postmenopausal women and men also had higher mortality rates, suggesting hormonal changes may influence immune responses and neurodegeneration.
The findings highlight the need for personalized MS care based on life stage, with premenopausal women monitored for relapses and postmenopausal women and men targeted for disability and neurodegeneration prevention.
La menopausia altera el inicio y la progresión de la EM en las mujeres, afectando los síntomas, las comorbilidades y la mortalidad, según un estudio realizado en 2025.