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An $18.7 million grant funds a Newcastle-led team to develop new DIPG brain cancer treatments, aiming for clinical trials within five years.
A Newcastle-led research team, led by Professor Matt Dun, has received an $18.7 million federal grant to develop new treatments for high-grade gliomas, aggressive brain cancers affecting over 2,000 Australians each year.
Inspired by the stories of Neil Armstrong’s daughter and Dun’s own daughter Josephine, who both battled diffuse intrinsic pontine glioma (DIPG), the team is working to overcome the blood-brain barrier and target genes driving the cancer’s spread.
The project, involving institutions including UNSW Sydney, the Children’s Cancer Institute, and the University of Queensland, aims to bring new therapies into clinical trials within five years.
One drug, paxalisib, already received accelerated FDA approval and was the first of its kind administered to a child with DIPG.
Researchers are also advancing precision radiation techniques, with the long-term goal of transforming uniformly fatal brain tumors into manageable conditions through innovation and collaboration.
Una subvención de 18,7 millones de dólares financia a un equipo liderado por Newcastle para desarrollar nuevos tratamientos de cáncer cerebral DIPG, con el objetivo de ensayos clínicos dentro de cinco años.