49ers star pass-rusher Nick Bosa exited Week 3 game early with a knee injury, sidelined for the rest of the game.

Star 49ers pass-rusher Nick Bosa left Sunday’s Week 3 game against the Arizona Cardinals early in the first quarter with a knee injury, limping off the field and later ruled out for the remainder of the game. He was seen signaling a thumbs-down to the crowd before heading to the medical tent. Bosa, a five-time Pro Bowler, had been playing effectively against the Cardinals’ offensive line and was a key part of San Francisco’s defense. His absence comes amid ongoing injury issues for the 49ers, who already miss quarterback Brock Purdy, tight end George Kittle, and wide receiver Jauan Jennings. Rookie defensive lineman Mykel Williams also exited briefly but later returned. With Bosa sidelined, the 49ers turned to backups like Bryce Huff and Yetur Gross-Matos to generate pressure. The team’s defensive depth is now under increased strain as they face a tough NFC West matchup.