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flag A yearlong mouse study links long-term keto diet use to increased metabolic risks like fatty liver and high blood fat, despite short-term weight loss.

flag A yearlong mouse study published in Science Advances on September 19, 2025, finds that while the ketogenic diet may aid short-term weight loss, long-term use could increase risks to metabolic health, including fatty liver, high blood fat levels, and impaired glucose regulation. flag Mice on a high-fat keto diet showed elevated triglycerides and cholesterol, insulin secretion issues, and glucose intolerance, though some effects reversed after returning to a normal diet. flag Researchers caution that despite weight loss benefits, the diet’s long-term impact on liver and cardiovascular health remains concerning, urging further human studies to assess safety.

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