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A yearlong mouse study links long-term keto diet use to increased metabolic risks like fatty liver and high blood fat, despite short-term weight loss.
A yearlong mouse study published in Science Advances on September 19, 2025, finds that while the ketogenic diet may aid short-term weight loss, long-term use could increase risks to metabolic health, including fatty liver, high blood fat levels, and impaired glucose regulation.
Mice on a high-fat keto diet showed elevated triglycerides and cholesterol, insulin secretion issues, and glucose intolerance, though some effects reversed after returning to a normal diet.
Researchers caution that despite weight loss benefits, the diet’s long-term impact on liver and cardiovascular health remains concerning, urging further human studies to assess safety.
Un estudio de ratones de un año de duración vincula el uso a largo plazo de la dieta ceto con un aumento de los riesgos metabólicos como el hígado graso y el alto contenido de grasa en la sangre, a pesar de la pérdida de peso a corto plazo.