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Sugary drinks fuel colorectal cancer spread in lab models by activating SORD, a target for potential therapies.
A new study from the University of Texas MD Anderson Cancer Center, published September 19, 2025, in Nature Metabolism, finds that the glucose-fructose mix in sugary drinks fuels metastasis in advanced colorectal cancer in preclinical models by activating the enzyme SORD, which boosts glucose metabolism and triggers a cholesterol-related pathway linked to cancer spread.
Blocking SORD reduced metastasis even with sugar intake, pointing to a potential therapeutic target.
The research adds to evidence that diet influences cancer progression beyond obesity, suggesting that reducing sugary drink consumption, targeting SORD, or repurposing statins may help limit metastasis.
The findings underscore the importance of dietary considerations in cancer care, especially given high sugar levels in many nutritional supplements and juices recommended for patients.
Further clinical studies are needed to confirm these results.
Las bebidas azucaradas alimentan la propagación del cáncer colorrectal en modelos de laboratorio mediante la activación de SORD, un objetivo para posibles terapias.