Kyler Murray faces a tough test against the 49ers' elite pass defense in a key Week 3 matchup.

Kyler Murray leads the Arizona Cardinals into a Week 3 showdown against the San Francisco 49ers, whose strong pass defense has limited quarterbacks to just 166 yards per game. Murray has thrown for 383 yards with a 70.4% completion rate and three touchdowns in two games, while also rushing for 70 yards. The 49ers have yet to allow a 300-yard passing game and rank among the league’s best in defending the pass. Arizona’s offense passes on 52.4% of plays and ranks 12th in scoring, while the Cardinals’ defense struggles to stop drives. The game hinges on whether Murray can overcome a disciplined 49ers defense and whether Arizona’s secondary can contain San Francisco’s drive-extending offense.