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flag Nitazenes, potent synthetic opioids 20x stronger than fentanyl, are driving a deadly surge in U.S. overdoses, evading detection and Narcan.

flag A resurgence of Nitazenes—potent synthetic opioids 20 times stronger than fentanyl—poses a growing public health threat in the U.S., according to medical experts and the DEA. flag Originally developed in the 1950s but never approved for medical use, these drugs are now being manufactured in China and mixed into other illicit drugs, leading to a rise in overdoses. flag Unlike fentanyl, Nitazenes are resistant to Narcan, requiring multiple doses for reversal, and standard drug tests often fail to detect them, complicating treatment and diagnosis. flag Over 90 fatal overdoses linked to Nitazenes were reported in Tennessee between 2019 and 2023. flag Experts urge expanded access to naloxone and drug testing strips, while calling for more research on long-term effects and treatment responses.

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