Venus Williams, 45, loses first Grand Slam match in two years at U.S. Open, ending her run.

45-year-old tennis legend Venus Williams lost her first Grand Slam match in two years at the U.S. Open, falling to 11th-seeded Karolina Muchova 6-3, 2-6, 6-1. Williams, a seven-time major singles champion, became the oldest singles player at the U.S. Open since 1981. Meanwhile, Mexico's Renata Zarazua pulled off a surprise win over No. 6 seed Madison Keys, her first victory over a top-20 player.