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Scientists find a protein that makes bone cancers resist immunotherapy, offering new treatment hopes.
Researchers have identified a protein, DKK1, produced by bone metastases that reprograms immune cells, making cancers in bones resistant to immunotherapy.
This discovery suggests that blocking DKK1 could improve immunotherapy's effectiveness against bone tumors, which currently have limited treatment options.
Additionally, CHI3L3 may serve as a biomarker to tailor treatments for patients with high immune resistance.
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Los científicos encuentran una proteína que hace que los cánceres de hueso resistan la inmunoterapia, ofreciendo nuevas esperanzas de tratamiento.