Detroit Lions face a grueling 2025 NFL season with five prime-time games and nine playoff rematch opponents.

The Detroit Lions' 2025 NFL schedule features five prime-time games and includes a tough lineup with nine 2024 playoff teams. The season starts with a road game against the Green Bay Packers on September 7 and includes a Thanksgiving Day game against Green Bay and a Christmas Day match against the Minnesota Vikings. The Lions will face a challenging 17-game schedule with a bye in Week 8.